Downstream Processing (DSP)
After the production of target molecules (Monoclonal Antibodies (mAbs), enzymes, complex glycoproteins, or hormones), isolation and purification from the complex mixture is a pivotal step. Downstream Processing (DSP) is our quality guarantee for optimal, high-purity end products.
To this end, we develop cost-efficient, customized, and scalable protein purification processes. Our DSP experts identify Critical Quality Attributes (CQA) throughout the purification process, and continuous quality control guarantees the final product's quality and purity.
Key Downstream Processing Services
- Various chromatographic methods: Affinity, IEX (Ion-Exchange), HIC (Hydrophobic Interaction), and multimodal chromatography.
- Wide range of formats: From 96-well filter plates to large-scale column formats.
- State-of-the-art systems: Use of modern FPLC (ÄKTA)* and UF/DF (Ultrafiltration/Diafiltration) systems.
- Continuous monitoring: Product quality monitoring throughout the entire DSP process.
- Technology transfer: Seamless technology transfer packages provided to our customers.
Our Commitment to Quality & Efficiency
- Experience with various classes of recombinant proteins, e.g., antibodies (IgGs), enzymes, and peptide hormones.
- Reproducible, scalable, and cost-efficient DSP processes.
- Established platform process for Monoclonal Antibodies (mAbs).
- Customized purification processes developed for unique molecules.
- Short development time achieved by parallelizing with cell line development.
- Fully traceable documentation and batch records.
*ÄKTA is a registered trademark of Cytiva. Our team is always on hand to advise you on any aspects of downstream processing.
To discuss your purification needs or request more technical details
Contact our technical experts