Upstream Processing (USP)
Upstream processing (USP) is a crucial stage in the large-scale manufacture of monoclonal antibodies, enzymes, complex glycoproteins, and hormones. It's the key to creating scalable bioprocesses.
With our many years of experience and outstanding specialist expertise, we guarantee fast and reliable development of robust, efficient and scalable bioprocesses. This later allows for maximum product concentrations with optimal quality and purity.
Our USP Services
- Process optimization
- Upscaling and Scale-up studies
- Feed and media adaptation (using First CHOice®)
- Integration of customized processes
- Technology transfer to customer
Critical Process Optimization
We cover a wide spectrum of upstream processing activities: from parallel experiments on a small scale in Ambr® 15 bioreactors (clone screening) to cultivation in 5-litre bioreactors (scale-up).
Our USP team works closely with you to identify and optimize all critical process parameters (CPPs):
- Media composition and nutrient strategy
- Inoculation density and cell viability monitoring
- Temperature and pH value control
- Dissolved oxygen (DO) and stirring speed optimization
For questions about integrating your existing cell line or a new project
Contact our technical experts